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Research

We work in interdisciplinary teams and leverage mechanical engineering principles (design, measurement, mechanics) to optimize the functional outcomes of clinical and surgical interventions and improve a patient’s quality of life. We use a systematic process to accomplish these goals. We design new instrumentation to characterize the variability associated with a surgical procedure or clinical intervention. We then use experiments and computer simulations to objectively establish the relationship between the variability of an intervention and functional outcomes. From those data, we can then parameterize clinical and surgical treatments to ensure that all patients achieve a high level of function. Using measurements as a quality control measure in order to subsequently optimize design and performance is a classic tenant of mechanical engineering. The lab is broadly researching the treatment of knee osteoarthritis. We are pioneering a new field of computer-assisted total knee arthroplasty, are researching focal cartilage defects, and are investigating the role of muscles in the lower extremity, especially those with weakened quadriceps.

Active Sponsored Projects

Using Intraoperative Measurements to Predict Postoperative Outcomes in TKA 
Sponsor:  National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056700) 
Collaborators: Matt Beal, Ajit Chaudhari, Jeff Granger, Andrew Glassman, Jeff Pan, Laura Schmitt

Patient-Specific Modeling of Total Knee Arthroplasty 
Sponsor:  National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR061085) 
Collaborators: Steve Piazza, Jeff Granger, Andrew Glassman, Ajit Chaudhari

Effects of Season of Play and Multiple Years of Play on Articular Cartilage Health in Collegiate Linemen
Sponsor:  National Football League Charities
Collaborators: Dave Flangian, Ajit Chaudhari,Michael Knopp, Metin Gurcan

Radial Distribution of Chondrocyte Cell Death in Medial and Lateral Femoral Condyles in Porcine Knees After Sub-Impact Loading

Sponsor: Arthroscopy Association of North America 
Collaborators: Dave Flangian, Sudha Agarwal

Computer-Assisted Total Knee Arthroplasty

Musculoskeletal Modeling and Simulation of Human Movement

Completed Sponored Projects

The Biomechanical Effects of Tibial Rotational Alignment Errors During Total Knee Arthroplasty 
Sponsor: The Orthopaedic Reserach and Education Foundation 
Collaborators: Matt Beal, Jeff Granger