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Siston, R.A., Hutter, E.E., Ewing, J.A., Hall, R..K., Granger, J.F., and Beal, M.D.: Intra-operative Laxity Following Total Knee Arthroplasty is Highly Variable and Different Than Osteoarthritic and Normal Knees. medRxiv 10.1101/2020.10.13.20212159



Caruthers, E.J., Schneider, G., Schmitt, L.C., Chaudhari, A.M.W., and Siston, R.A.: What are the Effects of Muscle Weakness on the Sit to Stand Transfer? Computer Methods in Biomechanics and Biomedical Engineering  Vol. 23, Issue 11, pp. 765-772, 2020

Roelker, S.A., Caruthers, E.J., Baker, R.K., Pelz, N.C., Chaudhari, A.M.W., and Siston, R.A.: Effects of Optimization Technique on Simulated Muscle Activations and Forces. Journal of Applied Biomechanics Vol. 36, Issue 4, pp. 259-278, 2020


Chaudhari, A.M.W., Schmitt, L.C., Freisinger, G.M., Lewis, J.M., Hutter, E.E., Pan,X., and Siston, R.A.: Perceived instability is associated with strength, not frontal knee laxity in patients with advanced knee osteoarthritis. Journal of Orthopaedic and Sports Physical Therapy Vol. 49 Issue 7, pp. 513-517, 2019

Hall, R.K., Ewing, J.A., Beal, M.D., Manning, D.W., and Siston, R.A.: Medially- Stabilized Total Knee Arthroplasty Does Not Alter Laxity and Balance in Cadaveric Knees. Journal of Orthopaedic Research, 37(2), 335-349, 2019.

Siston, R.A: CORR Insights®: Is There a Force Target That Predicts Early Patient-reported Outcomes After Kinematically Aligned TKA? Clinical Orthopaedics and Related Research 477(5), 1208-1210, 2019.

Couture, G, Chaudhari, A.M.W., Schmitt, L.C., Siston, R.A., and Pan, X: Associations Between Strength and Function Post Total Knee Arthroplasty Journal of Orthopaedic and Sports Physical Therapy 49(1), 2019.


Caruthers, E.J., Oxendale, K.C., Lewis, J., Chaudhari, A.M.W., Schmitt, L.C. and Siston, R.A.: Forces Generated by Vastus Lateralis and Vastus Medialis Decrease with Increasing Stair Descent Speed. Annals of Biomedical Engineering 46(4), 579-589, 2018


Roelker, S.A., Caruthers, E.J., Baker, R.K., Pelz, N.C., Chaudhari, A.M.W., and Siston, R.A.: Interpreting Musculoskeletal Models and Dynamic Simulations: Causes and Effects of Differences Between Models. Annals of Biomedical Engineering Nov;45(11):2635-2647, 2017.

Freisinger, G.M., Hutter, E.E., Lewis, J., Granger, J.F., Glassman, A.H., Beal, M.D., Pan, X, Schmitt, L.C., Siston, R.A., and Chaudhari, A.M.W.: Relationships Between Varus-Valgus Laxity of the Severely Osteoarthritic Knee and Gait, Instability, Clinical Performance, and Function. Journal of Orthopaedic Research Aug;35(8):1644-1652, 2017.

Thoma, L.M., McNally, M.P., Chaudhari, A.M.W., Best, T.M., Flanigan, D.C., Siston, R.A., and Schmitt, L.C.: Differential knee joint loading patterns during gait for individuals with tibiofemoral and patellofemoral articular cartilage defects in the knee. Osteoarthritis and Cartilage  Jul;25(7):1046-1054, 2017

Freisinger, G.M., Schmitt, L.C., Wanamaker, A.B., Siston, R.A., and Chaudhari, A.M.W.: Tibiofemoral Osteoarthritis and Varus–Valgus Laxity. Journal of Knee Surgery. Jun;30(5):440-451, 2017

Schloemer S.A., Thompson, J.A., Silder, A., Thelen, D.G., and Siston, R.A.: Age-Related Differences in Gait Kinematics, Kinetics, and Muscle Function: A Principal Component Analysis. Annals of Biomedical Engineering45(3), 695-710, 2017

Wei, W., Lambach, R.L., Jia, G., Flanigan D., Chaudhari, A.M.W., Wei, L., Rogers, A.,  Payne J., Siston, R.A., and Knopp, M.V.: Assessing the Effect of Football Play on Knee Articular Cartilage Using Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) Running title: dGEMRIC of knee articular cartilage. Magnetic Resonance Imaging Jan 12;39:149-156, 2017.


Caruthers EJ, Thompson JA, Chaudhari AM, Schmitt LC, Best TM, Saul KR, and Siston RA.: Muscle Forces and Their Contributions to Vertical and Horizontal Acceleration of the Center of Mass During Sit-To-Stand Transfer in Young, Healthy Adults. Journal of Applied Biomechanics, Oct;32(5):487-503, 2016.

Thoma, L.M., McNally, M.P., Chaudhari, A.M., Flanigan, D.C., Best, T.M., Siston R. A.,  and Schmitt, L.C.: Muscle Co-contraction During Gait in Individuals with Articular Cartilage Defects in the Knee. Gait & Posture 48, 68-73, 2016

Everhart JS, Flanigan DC, Chaudhari AM, Siston RA. Tibiofemoral joint subchondral surface conformity: Individual variability with race and sex-specific trends. Knee. 23(5):770-76, 2016

Ewing, J.A., Kaufman, M.K., Hutter, E.E., Granger, J.F., Beal, M.D., Piazza, S.J., and Siston R.A: Estimating Patient-Specific Soft-Tissue Properties in a TKA Knee. Journal of Orthopaedic Research. Mar 34(3), 435-43, 2016.

Peters, K.M., Hutter, E. E., Siston R. A.,  Bertran, J., and Allen, M.J.: Surgical Navigation Improves the Precision and Accuracy of Tibial Component Alignment in Canine Total Knee Replacement. Veterinary Surgery 45(1), 52-59, 2016


Lewis, J., Freisinger, G., Pan, X., Siston R. A., Schmitt, L.C., and Chaudhari, A.M.W.: Changes in Lower Extremity Peak Angles, Moments, and Muscle Activations During Stair Climbing at Different Speeds. Journal of Electromyography and Kinesiology 25(6), 982-989, 2015.

Hutchinson, J.R., Rankin, J.W., Rubenson, J., Rosenbluth, K.H., Siston, R.A., Delp, S.L. Musculoskeletal modelling of an ostrich (Struthio camelus) pelvic limb: influence of limb orientation on muscular capacity during locomotion. Peer J, June 11, 2015

Knapik D.M., Harrison, R.K., Siston R.A., Agarwal S., Flanigan D.C.: Impact of  Lesion Location and the Progression of Osteoarthritis in a Rat Knee Model. Journal of Orthopaedic Research  33(2), 237-245, 2015.

Lathrop, R.L., Young, J., Flanigan D.C., Siston, R.A, and Chaudhari, A.M.W.:  Knee Joint Loading during Lineman-Specific Movements in American Football Players. Journal of Applied Biomechanics June, 31(3): 142-148,2015


Harris, J.D., Quatman, C.E., Manring, M.M., Siston, R.A, and Flanigan, D.C.: How to Write a Systematic Review. American Journal of Sports Medicine Nov; 42(11):2761-8, 2014

Lathrop-Lambach, R.L, Asay, J.L, Jamison, S.T., Pan, X, Schmitt, L.C., Blazek, K., Siston, R.A., Andriacchi, T.P., and Chaudhari, A.M.W.: Evidence for Joint Moment Asymmetry in Healthy Populations During GaitGait and Posture 40(4):526-531, 2014

Thoma L.M., Flanigan D.C., Chaudhari, A.M. W., Siston R.A., Best T.M., and Schmitt L.C.: Quadriceps femoris strength and sagittal plane knee biomechanics during stair ascent in individuals with articular cartilage defects in the knee. Journal of Sport Rehabilitation Aug; 23(3):259-69, 2014.

Everhart, J. S,  Siston, R.A. and Flanigan, D.C.:   Tibiofemoral subchondral surface ratio (SSR) is a predictor of osteoarthritis symptoms and radiographic progression: data from the Osteoarthritis Initiative (OAI) Osteoarthritis and Cartilage 22(6):771-78, 2014.

Flanigan, D.C., Harris, J.D., Jia, G., Choi, S., Siston, R.A, Randazzo, J.L., and Knopp, M.: The Effect of Chondral Defect Size, Shape, and Location on MRI Diagnostic Performance in the Porcine Knee. Orthopaedics 37(4), e322-7, 2014.

Flanigan, D.C., Harris J.D., Brockmeier, P.M. Lathrop, R.L., and Siston, R.A.: The Effects of Defect Size, Orientation, and Location on Subcondral Bone Contact in Oval-Shaped Experimental Cartilage Defects. Knee Surgery, Sports Traumatology, Arthroscopy 22(1), 174-80, 2014.

Behery, O.A., Siston, R.A, Harris, J.D., and Flanigan, D.C.: Treatment of Cartilage Defects of the Knee: Expanding on the Existing Algorithm. Clinical Journal of Sports Medicine 24(1), 21-30, 2014


Knapik D.M., Harris J.D., Pangrazzi G., Griesser M.J., Siston R.A., Agarwal S., Flanigan D.C.: The Basic Science of Continuous Passive Motion in Promoting Knee Health: A Systematic Review of Studies in a Rabbit Model. Arthroscopy: The Journal of Arthroscopic and Related Surgery 29(10), 1722-1731, 2013.

Thompson, J.A., Chaudhari, A.M.W, Schmitt, L.C., Best, T.M, and Siston, R.A.: Gluteus Maximus and Soleus Muscles Compensate for Simulated Quadriceps Atrophy and Activation Failure During Walking. Journal of Biomechanics 46(13), 2165-2172, 2013

Harris, J.D., McNeilan ,R., Siston, R.A., and Flanigan, D.C.: Survival and clinical outcome of isolated high tibial osteotomy and combined biological knee reconstruction. The Knee 20(3) 154-161, 2013.

Behery, O.A., Siston, R.A, Karnes, J.M., Harris, J.D., and Flanigan, D.C.: Factors Influencing the Outcome of Autologous Chondrocyte Implantation: A Systematic Review. Journal of Knee Surgery 26(3) 203-211, 2013.

Hutter, E.E., Granger, J., Beal, M.D., and Siston, R.A.: Is There a Gold Standard for TKA Tibial Component Rotational Alignment? Clinical Orthopaedics and Related Research. 471(5):1646-1653, 2013.

Trinh, T.Q., Harris, J.D., Siston, R.A, and Flanigan, D.C.: Improved outcomes with combined autologous chondrocyte implantation and patellofemoral osteotomy versus isolated autologous chondrocyte implantation. Arthroscopy: The Journal of Arthroscopic and Related Surgery 29(3) 566-574, 2013.

Campbell, A.B., Knopp, M.V., Kolovich, G., Wei, W., Jia, G, Siston, R.A., and Flanigan,D.C.: Preoperative MRI Underestimates articular Cartilage Defect Size Compared to Arthroscopy. American Journal of Sports Medicine. 41(3):590-95, 2013.

Siston, R.A, Geier, D., Bishop, J., Jones, G., Kaeding, C., Granger, J., Skaife, T., May, M., and Flanigan, D.C.: The High Variability in Sizing Knee Cartilage Defects. The Journal of Bone and Joint Surgery AM 95(1):70-75, 2013.


Harris, J.D., Brophy, R.H., Jia, G., Price, B., Knopp, M., Siston, R.A, and Flanigan, D.C.: Sensitivity of Magnetic Resonance Imaging for Detection of Patellofemoral Articular Cartilage Defects. Arthroscopy: The Journal of Arthroscopic and Related Research 28(11):1728-1737, 2012

Elguizaoui, S., Harris, J.D., Parsons, E., Flanigan, D.C., and Siston, R.A.: Proud Osteochondral Autograft versus Synthetic Plugs – Contact Pressures with Cyclical Loading in a Bovine Knee Model. Knee 19(6):812-817,2012

Siston, R.A, Maack, T.L., Hutter, E.E., Beal, M.D., and Chaudhari, A.M.W.: The Design and Cadaveric Validation of a Novel Device to Measure Knee Stability During Total Knee Arthroplasty. ASME Journal of Biomechanical Engineering 134, 115001-1 - 115001-7, 2012


Lathrop, R.L., Chaudhari, A.M.W., and Siston, R.A.: Comparative Assessment of Bone Bose Estimation Using Point Cluster Technique and OpenSim. ASME Journal of Biomechanical Engineering 133(11), 114503-1 – 114503-6, 2011.

Harris, J.D., Siston, R.A., Brophy, R.H., Lattermann, C., Carey, J.L., and Flanigan, D.C.: Failures, re-operations, and complications after autologous chondrocyte implantation - A systematic review. Osteoarthritis and Cartilage (19), 779-791, 2011.

Thompson,J.A.., Hast M.W., Granger, J.F., Piazza, S.J., and Siston, R.A: Biomechanical Effects of Total Knee Arthroplasty Component Malrotation: A Computational Simulation. Journal of Orthopaedic Research Jul;29(7):969-75, 2011.

Harris, J.D., Cavo, M., Siston, R.A., and Flanigan, D.C.: Biological knee reconstruction - A systematic review of combined meniscal allograft transplantation and cartilage repair or restoration. Arthroscopy: The Journal of Arthroscopic and Related Research 27(3) 409-418, 2011. 

Harris, J.D., Solak, K.K., Siston, R.A., Litsky, A.L., Richards, J., and Flanigan, D.C.: Contact pressure comparison of proud osteochondral autograft plugs versus proud synthetic plugs: A biomechanical study in human cadaver knees. Orthopedics 34(2) 97, 2011.


Fazalare, J.A., Griesser, M.J., Siston, R.A., and Flanigan, D.C.: The use of continuous passive motion following knee cartilage defect surgery: a systematic review. Orthopedics 33(12) 878, 2010.

Flanigan, D.C., Brockmeier, P.M., Harris, J. D., and Siston, R.A.:  The Effects of Lesion Size and Location on Subchondral Bone Contact in Experimental Cartilage Defects in a Bovine Model. Arthroscopy: The Journal of Arthroscopic and Related Research 26(12) 1655-1661, 2010.

Flanigan, D.C., Harris, J.D., Trinh, T. Siston, R.A., and Brophy, R.H.: Prevalence of Chondral Defects in Athletes' Knees: A Systematic Review. Medicine & Science in Sports & Exercise. Vol. 42 (10), 1795-1801, 2010. 

Harris, J.D., Siston, R.A., Pan, X., and Flanigan, D.C.: Autologous Chondrocyte Implantation- A Systematic Review. The Journal of Bone and Joint Surgery AM  92(12):2220-2233, 2010. 

Harris, J.D., Brophy, R.H, Siston, R.A., and Flanigan, D.C.,: Treatment of Chondral Defects in the Athlete's Knee:  A Systematic Review. Arthroscopy: The Journal of Arthroscopic and Related Research Vol 26, No. 6 (June): 841-852, 2010. 

Howell, S.M., Kuznik, K., Hull, M.L., and Siston, R.A: Longitudinal Shapes of the Tibia and Femur are Unrelated and Variable. Clinical Orthopaedics and Related Research 468 (4):1142-1148, 2010.


Chen, C.A., Lu, W., John, C.T., Hargreaves, B.A., Reeder, S.B., Delp, S.L., Siston, R.A., and Gold, G.E. Multi-Echo IDEAL-GRE Water-Fat Separation for Rapid Assessment of Cartilage Morphology: Initial Experience. Radiology, vol 252: 561-567, 2009.

Van Gorp, C.C., Falk, J.V., Kmiec, S.J., and Siston, R.A.: The Reamer/Irrigator/Aspirator Reduces Femoral Canal Pressure in Simulated TKA. Clinical Orthopaedics and Related Research 467(3): 805-809, 2009. 


Cromie, M.J., Siston, R.A., Giori, N.J., and Delp, S.L.: Posterior Cruciate Ligament Removal Contributes to Abnormal Knee Motion During Posterior Stabilized Total Knee Arthroplasty. The Journal of Orthopaedic Research 26(11):2098-2104, 2008.

Siston, R.A., Cromie, M.J., Gold, G.E., Goodman, S.B., Maloney, W.J., Delp, S.L., and Giori, N.J. Averaging Different Alignment Axes Improves Femoral Rotational Alignment in Computer-Navigated Total Knee Arthroplasty. The Journal of Bone and Joint Surgery AM 90(10): 2098-2104, 2008.

Howell, S.M., Kuznik, K., Hull, M.L., and Siston, R.A.: Results of an Initial Experience with Custom-Fit Positioning Total Knee Arthroplasty in a Series of 48 Patients. Orthopedics 31(9): 857-863, 2008.


Siston, R.A., Goodman, S.B., Delp, S.L.,and Giori, N.J. Coronal plane stability before and after total knee arthroplasty. Clinical Orthopaedics and Related Research 463: 43-49, 2007

Siston, R.A., Giori, N.J., Goodman, S.B., and Delp, S.L.: Surgical navigation for total knee arthroplasty: A perspective. Journal of Biomechanics, vol 40, pp 728-735, 2007.


Siston, R.A., Goodman, S.B., Patel, J.J., Delp, S.L., and Giori, N.J.: The High Variability of Tibial Rotational Alignment in Total Knee Arthroplasty. Clinical Orthopaedics and Related Research 452: 65-69,2006.

Siston, R.A., Giori, N.J., Goodman, S.B.,and Delp, S.L.: Intraoperative passive kinematics of osteoarthritic knees before and after total knee arthroplasty.Journal of Orthopaedic Research, vol 24, pp 1607- 1614, 2006.

Siston, R.A. and Delp, S.L: Evaluation of a new algorithm to determine the hip joint center. Journal of Biomechanics, vol 39, pp 125–130, 2006.


Siston, R.A., Patel, J.J, Gooidman, S.B., Delp, S.L., and Giori, N.J.: The Variability of Femoral Rotational Alignment in Total Knee Arthroplasty. Journal of Bone and Joint Surgery, vol 87, pp 2276-2280, 2005.

Siston, R.A., Daub, A.C., Giori, N.J., Goodman, S.B., and Delp, S.L.: Evaluation of Methods That Locate the Center of the Ankle for Computer-assisted Total Knee Arthroplasty. Clinical Orthopaedics and Related Research, vol 439, pp 129–135, 2005.